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With the rapid advancement of biotechnology, it is foreseeable that fusion protein technology will have increasing importance in creating novel protein therapeutics and in improving the performance of current protein drugs. In the present study, we propose a machine learning
The receptor-binding affinity inside the endosomes determines different subsequent intracellular processing for the fusion proteins, and ultimately affects the plasma half-life of the fusion proteins. Similarly, a protease present in the lysosome, cathepsin B, has been applied for targeted intracellular
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